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The ACT podcast program, ToxChats ©, reports on cutting-edge news in toxicological research from around the globe. The program features interviews with experts and a review of the current advances. Tune into the podcast using a internet connection to learn about breakthroughs and regulatory developments in toxicological research and more.

The views and opinions expressed in this podcast are those of the guest speakers and do not necessarily reflect the official policy or position of the American College of Toxicology. For the College’s policy on the ethical treatment of animals in research, please see our comprehensive policy statement at

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Episode 12: Member Spotlight with Inaugural Mildred Christian Women’s Leadership in Toxicology Award Recipient

Release Date: December 12, 2018 Download mp3 Share

Episode 12: Member Spotlight with Inaugural Mildred Christian Women’s Leadership in Toxicology Award Recipient is the first episode of Scientist in the Spotlight, a podcast produced by ToxChats© and hosted by the Early Career Professional Subcommittee. In this episode, we spoke with Dr. Hanan Ghantous, supervisor in the Division of Anti-Viral Products in the Office of New Drugs, at the US FDA. Dr. Ghantous discussed her career transitions from industry to regulatory toxicology and provided advice for early career professionals. Additionally, Dr. Ghantous provided a brief history of how Mildred Christian helped shape ACT, and why the award was created in her honor.


Episode 11: In Vitro and Alternative Models for Regulatory Submission

Release Date: December 3, 2018 Download mp3 Share

In this two-chapter episode, in vitro and alternative models for regulatory submissions were explored from both an industry and government perspective. In the first chapter, Dr. Clive Roper, the head of In Vitro Sciences at Charles River Laboratories, and Dr. Lauren Black, a senior scientific advisor at Charles River Laboratories discuss the current landscape of in vitro and alternative models and share their thoughts about future directions of the field. In the second chapter, Dr. Paul Brown, the associate director of pharmacology and toxicology in the Office of New Drugs in the Center for Drug Evaluation and Research at the US Food and Drug Administration, discusses the acceptance of in vitro models for safety evaluations and the value of integrative toxicology.


Episode 10: Scientific Liaison Coalition

Release Date: November 15, 2018 Download mp3 Share

In this podcast the 2018–19 chairperson of the Scientific Liaison Coalition (SLC), Ken Hastings, highlights how the SLC provides the opportunity for societies to expand their outreach by partnering on a global basis with other societies to advance science to improve human and environmental health and well-being. The SLC is a nimble coalition of scientific, biomedical, and health-based societies working collaboratively on cutting-edge webinars, conferences, and sessions/continuing education courses at scientific meetings. More information about upcoming events can be found on the SLC website.


Episode 9: ACT Annual Meeting in West Palm Beach: Highlights and Preview

Release Date: October 8, 2018 Download mp3 Share

In this podcast, 2017–18 ACT President, Andy Kiorpes, provides insight into the upcoming ACT meeting in West Palm Beach, Florida and discusses some new initiatives ACT is implementing to reorganize and restructure the College to best serve the membership.


Episode 8: Regulation of E-Cigarettes

Release Date: July 19, 2018 Download mp3 InterACT Discussion Share

In this episode, Dr. Arianne Motter, a toxicologist with the Center for Drug Evaluation and Research at the US Food and Drug Administration, discusses the complex regulation of e-cigarettes at the FDA and the issues that toxicologists face when evaluating the potential these products have to reduce harm and the risk of tobacco-related disease. At the time of recording, Dr. Motter was a toxicologist with the Center for Tobacco Products at the FDA.


Episode 7: The Opioid Epidemic

Release Date: April 26, 2018 Download mp3 InterACT Discussion Share

In this episode of ToxChats, the opioid epidemic was discussed from a preclinical drug development perspective with Dr. Carrie Blum, Associate Director, Toxicology at Sunovion Pharmaceuticals and Dr. Mary Jeanne Kallman, VP and consultant at her own company Kallman Preclinical Consulting LLC.


Episode 6: Unique Identity Podcast

Release Date: March 6, 2018 Download mp3 InterACT Discussion Share

The goal of this podcast was to get an understanding of how ACT is different from other organizations and what makes ACT unique. In this episode, several meeting attendees were interviewed (aka ACT ToxChats stars!) at the 2017 ACT Annual Meeting in Palm Springs California. The individuals were asked about their involvement in ACT, what they think makes ACT unique, and what they love about the organization and the Annual Meeting. Members who have been part of ACT for over two decades, as well as those who have just recently discovered ACT, were among those interviewed.


Episode 5: 2017 ACT Annual Meeting in Palm Springs: Highlights and Preview

Release Date: September 21, 2017 Download mp3 Share

Tracey Zoetis, current president of ACT, we will be talking about the upcoming Annual Meeting of ACT in Palm Springs, California, in November.


Episode 4: Biomarkers

Release Date: September 7, 2017 Download mp3 Share

The role of biomarkers and their qualification in nonclinical and clinical development is discussed with Dr. William Mattes. Dr. Mattes is Director of the Division of Systems Biology, part of the FDA’s National Center for Toxicological Research in Jefferson, Arkansas.


Episode 3: Microbiome

Release Date: June 27, 2017 Download mp3 Share

Dr. Rodney Dietert has authored a number of books on the immune system and extensively published on the topics of noncommunicable diseases, immune dysfunction, and the microbiome. His latest book is titled “The Human Superorganism: How the Microbiome is Revolutionizing the Pursuit of a Healthy Life.”  In this podcast, Dr. Dietert discusses the microbiome in the context of nonclinical development of therapeutic drugs.


Episode 2: Oligonucleotide Therapeutics

Release Date: May 5, 2017 Download mp3 Share

Oligonucleotide therapeutics are all medications that utilize RNA- or DNA-based techniques as the effective entity. The nonclinical development of these therapeutics presents unique challenges and these are discussed here with Drs. Sven Korte from Covance, Brian Vuillemenot from Genentech and Scott Henry from Ionis Pharmaceuticals, all experts in oligo therapeutic development.


Episode 1: Introduction to the American College of Toxicology

Release Date: May 15, 2017 Download mp3 Share

The American College of Toxicology organizes a variety of educational opportunities throughout the year. This year is no different, however in addition to webinars and courses, ACT is launching podcasts. In addition, strategic planning meetings are held every three years to help keep the College stay on track with activities and objectives for the coming years. Current ACT President, Tracey Zoetis, discusses planned activities for this coming year and provides an update on the strategic meeting, which was held in February 2017.


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