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The ACT podcast program, ToxChats©, reports on cutting-edge news in toxicological research from around the globe. The program features interviews with experts and a review of the current advances. Tune into the podcast using a internet connection to learn about breakthroughs and regulatory developments in toxicological research and more.

Disclaimer
The views and opinions expressed in this podcast are those of the guest speakers and do not necessarily reflect the official policy or position of the American College of Toxicology. For the College’s policy on the ethical treatment of animals in research, please see our comprehensive policy statement at www.actox.org.

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The Scientific Approach to Address Uncommon Routes and Best Practices for Forming a Working Group

Release Date: October 7, 2019 Download mp3 Share

In this episode, Dr. Armaghan Emami, a toxicologist with the Center for Drug Evaluation and Research at the US FDA and 2019 award winner of Best Paper Published in International Journal of Toxicology for her first-author publication, "Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular" was interviewed. Dr. Emami discusses her inspiration for the collaborative paper, key considerations for the design and interpretation of studies utilizing an uncommon route, and provides advice to fellow scientists looking to form a working group or collaborative publication.


40th Annual Meeting Anniversary Special Program

Release Date: October 1, 2019 Download mp3 Share

In this podcast, Dave Serota chairman of the CHARGE40 Working Group is interviewed. Dave provides background on the plans for the upcoming Anniversary Special Program, "Reliving the History of ACT" scheduled on Sunday evening being held from 5:30 pm–7:00 pm at the ACT Annual Meeting, November 17, 2019 in Phoenix, Arizona.


Highlights and Preview of ACT 40th Annual Meeting

Release Date: September 27, 2019 Download mp3 Share

In this podcast, incoming ACT President, Lorrene Buckley and ACT Education Chair Grace Furman, provide a preview of the program at the upcoming 2019 Annual Meeting in Phoenix, Arizona.


CRISPR Then and Now: An Interview with Dr. Jacob Corn

Release Date: August 16, 2019 Download mp3 Share

Dr. Jacob Corn, ACT’s 2015 Plenary Lecturer, is a Professor of Genome Biology at the Swiss Federal Institute of Technology in Zurich. The Corn Laboratory develops next-generation genome editing and regulation technologies for fundamental biological discovery and to develop potential therapies for human genetic diseases. In this episode, he describes how CRISPR may impact the treatment of rare diseases, while providing context for drug safety evaluation. Potential applications and ethical considerations for livestock and human organ development is covered, in addition to primary concerns about the future of CRISPR. Dr. Corn shares what he considers to be the key milestones, greatest advancements, and unforeseen surprises in the evolution of CRISPR technologies.


Where Are They Now Series: the Rising Stars of ACT 

Release Date: October 17, 2019 Download mp3 Part 3 Share

Part 3: 2013 Early Career Professional Award Recipient, Lisa D. Beilke, MSPH, PhD, DABT, ERT

Lisa D. Beilke, MSPH, PhD, DABT, ERT received the Early Career Professional Award in 2013. Since receiving her award, Lisa transitioned from Principal Scientist in Aragon Pharmaceuticals to Sr. Director of Drug Safety at Tricida, Inc. and is now currently the President/CEO of Toxicology Solutions, Inc. Lisa also currently serves on the Editorial Board for International Journal of Toxicology.

 

Release Date: September 16, 2019 Download mp3 Part 2 Share

Part 2: 2017 Early Career Professional Award Recipient, Heidi Hsieh, PhD

Heidi Hsieh, PhD is currently a Study Director at Covance. She is one of only two past ACT members to have been awarded both the Early Career Professional Award in 2017 and the Furst Award in 2015. Since receiving her award, Heidi has continued her role as Study Director at Covance and currently serves on the Editorial Board for International Journal of Toxicology.

 

Release Date: May 28, 2019 Download mp3 Part 1 Share

Part 1: 2011 Early Career Professional Award Recipient, Melissa Rhodes, PhD, DABT and 2014 Early Career Professional Award Recipient, Ilona Bebenek, PhD, DABT

Celebrating the 40 year anniversary of the ACT Annual Meeting, past Early Career Professional Award
recipients are interviewed.


An Interview with Distinguished Scientist and Early Career Professional Award Recipients

Release Date: April 10, 2019 Download mp3 Share

In this podcast, Cheryl Lyn Walker, who received the 2018 Distinguished Scientist Award in Toxicology, and Kristina DeSmet, who received the 2018 Early Career Professional Award, react to being honored by the American College of Toxicology. Dr. Walker and Dr. DeSmet also share personal stories about how they became involved in toxicology and discuss their visions about the future of the field.

 


ACT’s Impact via Outreach and Sister Societies

Release Date: February 22, 2019 Download mp3 Share

In this podcast, the former ACT President, Tracey Zoetis, discusses recent and ongoing outreach initiatives by the ACT. American College of Toxicology engages in a variety of outreach initiatives, ranging from partnering with sister societies to service in the field of toxicology on an international level.

 


Scientist in the Spotlight Series: Inaugural Mildred Christian Women’s Leadership in Toxicology Award Recipient

Release Date: December 12, 2018 Download mp3 Share

In the first episode of Scientist in the Spotlight, a new podcast series produced by ToxChats© and hosted by the Early Career Professional Subcommittee of ACT. In this episode, we interviewed Dr. Hanan Ghantous, the award recipient of the Inaugural Mildred Christian Women’s Leadership in Toxicology Award. She is a supervisor in the Division of Anti-Viral Products in the Office of New Drugs, at the US FDA. Dr. Ghantous discussed her career transition from industry to regulatory toxicology and provided advice for early career professionals. Additionally, she provided a brief history of how Mildred Christian helped shape ACT, and why the award was created in her honor.

 


In Vitro and Alternative Models for Regulatory Submission

Release Date: December 3, 2018 Download mp3 Share

In this two-chapter episode, in vitro and alternative models for regulatory submissions were explored from both an industry and government perspective. In the first chapter, Dr. Clive Roper, the head of In Vitro Sciences at Charles River Laboratories, and Dr. Lauren Black, a senior scientific advisor at Charles River Laboratories discuss the current landscape of in vitro and alternative models and share their thoughts about future directions of the field. In the second chapter, Dr. Paul Brown, the associate director of pharmacology and toxicology in the Office of New Drugs in the Center for Drug Evaluation and Research at the US Food and Drug Administration, discusses the acceptance of in vitro models for safety evaluations and the value of integrative toxicology.

 


Scientific Liaison Coalition

Release Date: November 15, 2018 Download mp3 Share

In this podcast the 2018–19 chairperson of the Scientific Liaison Coalition (SLC), Ken Hastings, highlights how the SLC provides the opportunity for societies to expand their outreach by partnering on a global basis with other societies to advance science to improve human and environmental health and well-being. The SLC is a nimble coalition of scientific, biomedical, and health-based societies working collaboratively on cutting-edge webinars, conferences, and sessions/continuing education courses at scientific meetings. More information about upcoming events can be found on the SLC website.

 


ACT Annual Meeting in West Palm Beach: Highlights and Preview

Release Date: October 8, 2018 Download mp3 Share

In this podcast, 2017–18 ACT President, Andy Kiorpes, provides insight into the upcoming ACT meeting in West Palm Beach, Florida and discusses some new initiatives ACT is implementing to reorganize and restructure the College to best serve the membership.

 


Regulation of E-Cigarettes

Release Date: July 19, 2018 Download mp3 InterACT Discussion Share

In this episode, Dr. Arianne Motter, a toxicologist with the Center for Drug Evaluation and Research at the US Food and Drug Administration, discusses the complex regulation of e-cigarettes at the FDA and the issues that toxicologists face when evaluating the potential these products have to reduce harm and the risk of tobacco-related disease. At the time of recording, Dr. Motter was a toxicologist with the Center for Tobacco Products at the FDA.

 


The Opioid Epidemic

Release Date: April 26, 2018 Download mp3 InterACT Discussion Share

In this episode of ToxChats, the opioid epidemic was discussed from a preclinical drug development perspective with Dr. Carrie Blum, Associate Director, Toxicology at Sunovion Pharmaceuticals and Dr. Mary Jeanne Kallman, VP and consultant at her own company Kallman Preclinical Consulting LLC.

 


Unique Identity Podcast

Release Date: March 6, 2018 Download mp3 InterACT Discussion Share

The goal of this podcast was to get an understanding of how ACT is different from other organizations and what makes ACT unique. In this episode, several meeting attendees were interviewed (aka ACT ToxChats stars!) at the 2017 ACT Annual Meeting in Palm Springs California. The individuals were asked about their involvement in ACT, what they think makes ACT unique, and what they love about the organization and the Annual Meeting. Members who have been part of ACT for over two decades, as well as those who have just recently discovered ACT, were among those interviewed.

 


2017 ACT Annual Meeting in Palm Springs: Highlights and Preview

Release Date: September 21, 2017 Download mp3 Share

Tracey Zoetis, current president of ACT, we will be talking about the upcoming Annual Meeting of ACT in Palm Springs, California, in November.

 


Biomarkers

Release Date: September 7, 2017 Download mp3 Share

The role of biomarkers and their qualification in nonclinical and clinical development is discussed with Dr. William Mattes. Dr. Mattes is Director of the Division of Systems Biology, part of the FDA’s National Center for Toxicological Research in Jefferson, Arkansas.

 


Microbiome

Release Date: June 27, 2017 Download mp3 Share

Dr. Rodney Dietert has authored a number of books on the immune system and extensively published on the topics of noncommunicable diseases, immune dysfunction, and the microbiome. His latest book is titled “The Human Superorganism: How the Microbiome is Revolutionizing the Pursuit of a Healthy Life.”  In this podcast, Dr. Dietert discusses the microbiome in the context of nonclinical development of therapeutic drugs.

 


Oligonucleotide Therapeutics

Release Date: May 5, 2017 Download mp3 Share

Oligonucleotide therapeutics are all medications that utilize RNA- or DNA-based techniques as the effective entity. The nonclinical development of these therapeutics presents unique challenges and these are discussed here with Drs. Sven Korte from Covance, Brian Vuillemenot from Genentech and Scott Henry from Ionis Pharmaceuticals, all experts in oligo therapeutic development.

 


Introduction to the American College of Toxicology

Release Date: May 15, 2017 Download mp3 Share

The American College of Toxicology organizes a variety of educational opportunities throughout the year. This year is no different, however in addition to webinars and courses, ACT is launching podcasts. In addition, strategic planning meetings are held every three years to help keep the College stay on track with activities and objectives for the coming years. Current ACT President, Tracey Zoetis, discusses planned activities for this coming year and provides an update on the strategic meeting, which was held in February 2017.

 


















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