Practical Reproductive and Developmental Toxicology

This joint American College of Toxicology/Society for Birth Defects Research and Prevention course is designed to provide a basic understanding in reproductive and developmental biology and principles of various testing approaches for reproductive and developmental toxicology, with strong emphasis on the practical application of these principles and interpretation of nonclinical safety data as well as risk assessment. The intended audience for this course includes industrial and regulatory scientists, graduate students, and postdoctoral fellows.

Monday, May 22, 2023

Female Reproductive Biology/Toxicology, Aileen Keating, Iowa State University
Male Reproductive Biology/Toxicology, Justin Conley, US Environmental Protection Agency
Embryology: From Fertilization to Neural Tube/Somite Formation, E. Sid Hunter, US Environmental Protection Agency
Principles of Abnormal Development , Gerald Grunwald, Thomas Jefferson University
Normal and Abnormal Craniofacial Development, Robert Lipinski, ToxStrategies
Normal and Abnormal Development of the Musculoskeletal System and Limbs, John Rogers, ToxStrategies


Please join us for a reception following the course on Monday. This light-fare reception, which is included in the registration fee, allows for fellow course attendees, course organizers, and speakers to interact and network in a casual atmosphere. Hors d’oeuvres, plus drink tickets for beer and wine will be provided to registered participants.

Tuesday, May 23, 2023

Normal and Abnormal Development of the Cardiovascular Systems, Ida Washington, University of Vermont
Normal and Abnormal Development of the Respiratory and Digestive Systems, Terry Hrubec, Virginia Polytechnical Institute and State University
Normal and Abnormal Development of the Urogenital System, John Rogers, ToxStrategies
Normal and Abnormal Development of the Nervous System, Charles Vorhees, University of Cincinnati
Developmental Immunotoxicology, Jamie DeWitt, East Carolina University
Placental Biology and Toxicology, Josh Robinson, University of California at San Francisco
PK/ADME of Xenobiotics/Chemicals during Pregnancy/Lactation and in Fetus/Newborn, Hisham El Masri, US Environmental Protection Agency

Wednesday, May 24, 2023

Overview of Regulatory Reproductive and Developmental Toxicology, Alan Hoberman, Charles River Laboratories
Male/Female Fertility Testing, Donald Stump, Charles River Laboratories
Developmental Toxicity Testing, Christopher Bowman, Pfizer
Pre- and Postnatal Development/Multigeneration Testing/Juvenile Animals Toxicity Testing, Susan Laffan, GlaxoSmithKline
Data Interpretation, Alan Hoberman, Charles River Laboratories
Clinical Trials, Pregnancy Labelling and Post-market Monitoring, Kary Thompson, Janssen

Thursday, May 25, 2023

Risk Assessment for Pharmaceuticals, Tacey White, Tacey White Toxicology Consultant, LLC
Risk Assessment for Agricultural and Industrial Chemicals, Elizabeth Méndez, US Environmental Protection Agency
Practicum: Case Studies
Practicum: Hands-On Exercise in Small Groups with Facilitators
Practicum Moderators: Alan Hoberman, Charles River Laboratories; Donald Stump, Charles River Laboratories; Amy Lavin Williams, Exponent; John Rogers, ToxStrategies; Christopher Bowman, Pfizer; and Susan Laffan, GlaxoSmithKline

Friday, May 26, 2023*

Practicum: Wrap-Up Discussion
Cellular and Molecular Analysis of Development, Brian Johnson, Michigan State University
New Approach Methodologies (NAMs) for Developmental Screening and the Future of Risk Assessment, Jessica LaRocca, Corteva
Read-across for DART, George Daston, Procter & Gamble Company

Speakers, presentation topics, and/or format are subject to change.

Daily continental breakfast, breaks, and lunch are provided as part of the registration. Detailed course handouts will be provided electronically. Participants must bring a personal computer to view materials. Please ensure to download materials before arriving. Internet will not be provided.


Registration and Check-In: Monday, 7:30 am–8:00 am

Monday–Thursday, 8:00 am–5:00 pm. *Course ends at 1:15 pm on Friday, May 26

Course Organizers

John Rogers, PhD, ToxStrategies

Amy Lavin Williams, PhD, Exponent

Christopher Bowman, PhD, DABT, Pfizer

Elaine Francis, PhD, Sandcastle Toxicology Associates

Alan Hoberman, PhD, DABT, ATS, Charles River Laboratories

Christopher Lau, PhD, US Environmental Protection Agency

Narcisa Despoiu, ACT Staff Liaison

Registration Fees:

Early-Bird Registration
(Received by March 6)
Regular Registration
(March 7–May 19)
ACT/BDRP Member $1,500 $1,600
ACT/BDRP Student or Postdoc Member $995 $1,095
Nonmember $1,800 $1,900
Government $1,500 $1,600
ACT/BDRP Member Group Rate**
(3 or more from same company)
$1,350 $1,450
Nonmember Group Rate**
(3 or more from same company)
$1,650 $1,750
ACT/BDRP Member Group Rate**
(10 or more from same company)
$1,250 $1,350
Nonmember Group Rate**
(10 or more from same company)
$1,550 $1,650

**To take advantage of the group rate: Please send your completed registration forms to ACT Headquarters. You will not be able to select the group rate through the online registration. All three forms (or more) should be emailed at the same time.

Refund Policy: $100 Processing Fee will be charged before 3/9/23; 50% refund if canceled before 4/3/23; After 4/3/23, no fees will be refunded.

Registration Form

Masks Strongly Encouraged

The American College of Toxicology will follow current science-based information and is fully committed to taking appropriate precautions to provide a safe and healthy environment for participants of the course. ACT will continue to monitor the COVID-19 situation along with local and federal guidelines. Based on current health mandates, ACT will not require proof of vaccination or proof of a negative PCR test. However, the local mandates could change; therefore, we ask that individuals bring a mask and proof of vaccination on their person. You may also want to consider bringing an at-home COVID-19 test kit with you.

Mask wearing is a prudent measure to prevent spread of viruses and is strongly encouraged during the meeting. Additionally, vaccination has been proven to be effective in preventing hospitalization and death from COVID-19. ACT expects that course attendees use the CDC’s self-checker website daily. Should you feel unwell or suspect you have been exposed to COVID-19, we ask that you isolate. Please stay home if you feel sick.

Course Location

Gaithersburg Marriott Washingtonian Center
9751 Washingtonian Boulevard
Gaithersburg, MD 20878


Gaithersburg Marriott Washingtonian Center
9751 Washingtonian Boulevard
Gaithersburg, MD 20878
Tel: 301.590.0044
Hotel Reservations: 800.228.9290

Housing Deadline

Please refer to the ACT PRDT Room Block to make your housing reservation. The ACT PRDT meeting rate of $215 (plus tax) is offered over the dates of May 21-26, 2023, based on availability, and reservations must be made by April 28, 2023.


A personal laptop to view course materials and your computer charger are required. We suggest downloading all the course materials to your laptop prior to arriving at the course. Course materials will be provided approximately one week before the start of the course. Internet will not be provided in the course.