Aims and Scope. International Journal of Toxicology, formerly titled Journal of the American College of Toxicology, is the College’s sole official journal. Publishing fully refereed papers covering the entire field of toxicology, the International Journal of Toxicology addresses previously unpublished findings and assessments of the toxicity hazards of industrial chemicals, pharmaceutical agents, environmental contaminants, and other entities, while exploring their mechanisms of action relevant to human health. Each issue informs the reader on the full range of critical issues in toxicology, including:

• mechanisms of toxicity
• risk assessment and safety evaluation
• carcinogenicity
• reproductive and genetic toxicology
• epidemiology and clinical toxicology
• new approaches to toxicological testing
• alternatives to animal testing
• safety and regulatory toxicology

Submission of Manuscripts. The original and three photocopies of each manuscript should be submitted, along with a $50 manuscript handling fee (payable to the American College of Toxicology), to the Editor-in-Chief. A completed and duly signed transfer of copyright form must accompany the submission as well.

	Harihara M. Mehendale, PhD, DABT, FATS,
	Department of Toxicology,
	College of Pharmacy,
	The University of Louisiana at Monroe,
	700 University Avenue (Sugar Hall #306),
	Monroe, LA 71209-0495, USA.
	Fax: 318-342-1686.
	E-mail: mehendale@ulm.edu

     Authors are strongly encouraged to submit manuscripts electronically to the editor-in-chief. The file should be prepared using MS Word or WordPerfect and should be clearly labeled with the authors’ names, file name, software program, and the beginning date of submission. A hardcopy printout that exactly matches the file must be supplied. Each manuscript must be accompanied by a cover letter that should include a statement that it has not been published elsewhere and that it has not been submitted simultaneously for publication. The cover letter must include a separate statement disclosing the source of grant money, or unequivocally state that none of the authors have any conflicting interest with the submission of the manuscript. Authors are responsible for obtaining permission to reproduce copyrighted material from other sources and are required to sign an agreement for the transfer of copyright to the American College of Toxicology.

      The transfer of copyright agreement form is located in the journal. A completed and duly signed form should accompany the manuscript at the time of submission, regardless of whether the manuscript has been submitted electronically or by mail. All accepted manuscripts, artwork, and photographs become the property of the publisher.

      The manuscript should be typewritten, double-spaced, with one inch margins on all sides. The pages should be numbered consecutively throughout the paper. All titles should contain 6 to 12 words. Please provide a short version of the title suitable for the running head, not exceeding 50 character spaces. Each article should be summarized in an abstract of no more that 250 words. Abbreviations, diagrams, and reference to the text within the abstract should not be used.

      To ensure the manuscripts are style-compliant, consult the latest issue of the journal for stylistic relevant issues.

      The first page of the manuscript should contain the following: article title, the names and affiliations of all authors, an abbreviated form of the title, and the name, complete mailing address, telephone and fax numbers, and e-mail address of the person to whom all correspondence should be sent. The remaining text of the manuscript should be double-spaced. The second page should contain an abstract followed by keywords listed alphabetically.

      Original research articles should contain the following additional sections: Introduction, Materials and Methods, Results and Discussion. Review articles will also have these sections, although some variations may occur. Any study involving the use of animals should briefly describe the procedures employed for their humane care and use as promulgated by the ACT, NIH, or other regulatory guidelines.

References. References should be alphabetized by author and compiled in a separate section at the end of the manuscript. Please cite text by author and year. Reference style should follow The Chicago Manual of Style, 15th ed.,
e.g.:
Journal Article: Buters, J. T., J. Doehmer, and F. J. Gonzales. 1999. Cytochrone P450-null mice. Drug Metab. Rev. 31: 437-447.
Book: Hodgson, E., and R.C. Smart. 2001. Introduction to Biochemical Toxicology, New York: John Wiley & Sons.
Article in a Book: Mehendale, H. M. 2001. Application of isolated organ techniques in toxicology. In Principles and Methods of Toxicology, ed. A. W. Hayes, 1529-1584, Philadelphia: Taylor & Francis.
Illustrations. Illustrations such as, line drawings, halftones, photos, photomicrographs, etc., should be clean originals or digital files. Digital files are recommended for highest quality reproduction and should adhere to the following guidelines:

• 300 dpi or higher
• sized to fit on journal page
• EPS, TIFF, or PSD format only
• submitted as separate files, not embedded in text files

      Color illustrations will be considered for publication; however, the author will be required to incur the full cost involved with the printing and publication. The charge for the first page with color is $900.00. The next three pages with color are $450.00 each. A custom quote will be provided for color art totaling more than 4 journal pages. Good-quality color prints or files should be provided in their final size. The publisher has the right to refuse publication of color prints deemed unacceptable.
Tables and Figures. Tables and figures should not be embedded in the text, but should be included as separate sheets or files. A short descriptive title should appear above each table with a clear legend, and any footnotes suitably identified below. It is necessary that all units are included. Figures should be completely labeled, including any necessary size reduction. Figure legends should be typed and double-spaced on a separate sheet. All original figures should be clearly marked in pencil on the reverse side with the number, author’s name, and top edge.
Offprints. An offprint order form will accompany proofs. It should be completed and returned with proofs.

Conflict of Interest Statement. Authors are required to disclose any possible conflicts of interest. Sufficient disclosure, for authors submitting their manuscripts, may be constituted by divulging their affiliation as members of industrial or government organizations. Academic, nonprofit, consulting, advocacy, and all other authors are asked to disclose, under the subheading Acknowledgement, all sources of financial and material support for studies and manuscripts submitted.

Guidelines for Ethical Publications. A policy statement and guidelines for ethical publications is published in the first issue of the journal every volume year.