ACT Signature Webinar series provides accessible education to members of the toxicology community worldwide. These educational webinars cover current topics in toxicology and are presented by experts in the field, with backgrounds in government, industry, or academia.
The live Signature Webinars are held on a quarterly basis and are free to both ACT members and nonmembers. Each webinar is approximately 90 minutes, followed by a 30-minute questions and answers session with the speaker(s).
After the live webinar, nonmembers may purchase on-demand access of the webinar for a fee. On-demand access of the webinar allows for viewing for seven days. ACT members may continue viewing the on-demand webinar without a fee. Fees are accessed according to the membership status at the time of purchase and there are no refunds.
Signature Webinar
February 25, 2026, 11:30 AM–1:00 PM Eastern
Inside the Intrathecal Space and ICV Dosing: Practical Principles and Real-World Lessons in Nonclinical Study Design
In Collaboration with the American College of Toxicology’s Early Career Professional Subcommittee
SPEAKERS:
Technical Considerations for Intrathecal and Intracerebroventricular Routes: Essential Insights for Toxicologists
Stefania Cinquino, BSc
Intrathecal Administration in Nonhuman Primates: Technique, Study Designs, Challenges
Florian Timo Ludwig, PhD
Procedure-Related Microscopic Findings Secondary to Intrathecal Dosing of Test-Articles
Lisa Berman-Booty, VMD, PhD, DACVP
Intrathecal (IT) and intracerebroventricular (ICV) administration enable direct access to the central nervous system but introduce route-specific complexities in nonclinical study design, execution, and interpretation. This webinar translates those complexities into practical principles for toxicologists aiming to deliver sound risk assessment and regulatory-ready packages. The speakers will examine how administration parameters, surgical technique, catheter/device considerations, dosing paradigms, and species selection (rodent vs. nonrodent) shape data quality and translational relevance. Direct IT delivery can produce procedure-related microscopic findings from localized injury or irritation of CNS tissues; however, microscopic changes of similar character and/or severity may also arise from the test article (TA), complicating interpretation. Approaches that can be used to help differentiate procedure-related from TA-related microscopic changes will also be discussed.
On-Demand Access
On-demand Signature webinars are available for free to ACT members and $50 for nonmembers. Purchasing of the on-demand webinar provides unlimited viewing for seven days. Viewing is restricted to a single user only. Webinars are approximately 90 minutes with up to 30 minutes of audience questions and speaker answers. There are no cancelations or refunds allowed after the payment has been processed.
The following learning levels have been identified for ACT educational offerings.
Foundational (Basic)
Focuses on core skills or fundamental understanding of a topic (View library )
Advanced
The converse of basic, if not basic then advanced (View library )
Practical
How to do it—procedures, design, reporting, use of tools, tips, tricks, experiences, and/or advice
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Emerging
New, unusual, or uncommon techniques, modalities, ROA, guidance, tools/equipment (hardware and software), and/or changes to standard practice
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