American College of Toxicology

International Journal of Toxicology

NOW

Fully Covered by Medline

(Articles Searchable by PubMed)

The International Journal of Toxicology publishes fully refereed papers covering the entire field of toxicology, including research in risk assessment, general toxicology, carcinogenicity, safety evaluation, reproductive and genetic toxicology, epidemiology and clinical toxicology, mechanisms of toxicity, new approaches to toxicological testing, and alternatives to animal testing. Reviews and major symposia in the field are included.

Submissions by authors in the following areas are invited in addition to manuscripts describing original research in all areas of toxicology. Address all correspondence to the Editor-in-Chief. Also see the Instructions to Authors for more information.: Letters to the Editor: Letters should be addressed to the Editor with regard to any published papers. Also any letters regarding any information of interest to the readers of this journal are considered.; Book Reviews: Reviews on any recent Books of interest to the readers of this journal are welcome. These reviews should be submitted to Dr. Robert W. Kapp, Jr., the Book Editor.; State-of-the-Art Reviews: Any area of Toxicology, particularly in Regulatory Toxicology, International Harmonization, Risk Assessment and related areas.; Perspective-Counterperspective: Articles of opposing views in the form of a debate are highly welcome in any area of Toxicology. Examples of three main areas are: (1) Discussion of mechanisms of toxicity based on scientific evidence (2) Regulatory issues and Risk Assessment. State of the Science in areas of cancer and noncancer endpoints, animal to human extrapolation, incorporation of emerging mechanisms and concepts in risk assessment, and methodology of risk assessment. (3) Any contemporary issue. Environmental estrogens, risk assessment of metals such as Arsenic, threshold concept in cancer risk assessment, etc.; Enquiries regarding the publication of proceedings of meetings, and topical Symposia are welcome.

EDITOR-IN-CHIEF
Harihara M. Mehendale, Ph.D.
Department of Toxicology
University of Louisiana at Monroe

ASSOCIATE EDITORS
Bruce K. Bernard, Ph.D.
SRA International, Inc.

William J. Brock, Ph.D.
Brock Scientific Consulting, LLC

EDITORS EMERITI
Mildred S. Christian, Ph.D. (Founding Editor)
Robert M. Diener, D.V.M.

Upcoming Articles in Future Issues

Original Research Articles

Acute Toxicity of Synthetic Pyrethroid Cypermethrin to Freshwater Catfish Heteropneustes fossilis (Bloch)
Suchismita Saha and Anilava Kaviraj

A Toxicity Profile of Osteoprotegerin (IPG) in the Cynomolgus Monkey
Brenda B. Smith, Mary Ellen Cosenza, Audrey Mancini, Colin Dunstan, Richard Gregson, Steven W. Martin, Susan Y. Smith, Harold Davis

Immunohistochemical Changes in the Mouse Striatum Induced by the Pyrethroid Insecticide Permethrin
Julian T. Pittman, Celia A. Dodd, and Bradley G. Klein

A Functional Observational Battery (FOB) for Use in Canine Toxicity Studies: Development and Validation
Shayne C. Gad and S. E. Gad

Carboplatin-induced Oxidative Injury in Rat Inferior Colliculus
Kazim Husain, Craig Whitworth, Stephen Hazelrigg, and Leonard Rybak

Food Safety: Risk Assessment Methodology and Decision Making Criteria
William J. Brock, Joseph V. Rodricks, Alan Rulis, Vicki L. Dellarco, George M. Gray, and Richard W. Lane

Effect of Ketamine on Cocaine-Induced Immunotoxicity in Rats
H. Z. Rofael, R. M. Turkall, and M. S. Abdel-Rahman

In Vitro Inhibition of Blood Cholinesterase Activities from Horse, Cow and Rat by Tetrachlorvinphos
Subramanya Karanth and Carey Pope

Oxidative Stress in Rats after 60 Days of Hypergalactosemia or Hyperglycemia
Mary Otsyula, Matthew S. King, Ruth A. Sanders, and John B. Watkins III

Book Reviews

Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects
Lucio G. Costa and Clement E. Furlong

Chemeric Toxins: Mechanisms of Action and Therapeutic Applications (Cell and Molecular Mechanisms of Toxin Action) 1^st Edition
Haya Lorberboum-Galski and Philip Lazarovici

Symposia

Introduction: Issues On the Safety of Pharmaceutical and Food Excipients
Elaine V. Knight, Ph. D.

The Use of Unallowed Excipients
Marshall Steinberg, Ph. D.

Toxicity of Excipients-An FDA Perspective
Robert E. Osterberg and Norman A. See

CIR SUPPLEMENT #2

Final Report on the Amended Safety Assessment of Sodium Polynaphthalenesulfonate and Sodium Naphthalenesulfonate
F. Alan Andersen

Final Report on the Safety Assessment of Stearoxy Dimethicone, Dimethicone, Methicone, Amino Bispropyl Dimethicone, Aminopropyl Dimethicone, Amodimethicone, Amodimethicone Hydroxystearate, Behenoxy Dimethicone, C24-28 Alkyl Methicone, C30-45 Alkyl Dimethicone, C30-45 Alkyl Methicone, Cetearyl Methicone, Cetyl Dimethicone, Dimethoxysilyl Ethylenediaminopropyl Dimethicone, Hexyl Methicone, Hydroxypropyldimethicone, Stearamidopropyl Dimethicone, Stearyl Dimethicone, Stearyl Dimethicone, Stearyl Methicone, and Vinyldimethicone¹
Binu Nair

Final Report on the Amended Safety Assessment of Sodium Polynaphthalenesulfonate and Sodium Naphthalenesulfonate¹
F. Alan Andersen

Annual Review of Cosmetic Ingredient Safety Assessments¹
F. Alan Andersen

CIR SUPPLEMENT #3

Final Report on the Amended Safety Assessment of Diisopropyl Dimer Dilinoleate, Dicetearyl Dimer Dilinoleate, Diisostearyl Dimer Dilinoleate, Dioctyl Dimer Dilinoleate, Dioctyldodecyl Dimer Dilinoleate, and Ditridecyl Dimer Dilinoleate¹
Monice Zondlo Fiume

Final Report on the Safety Assessment of Sodium Sulfite, Potassium Sulfite, Ammonium Sulfite, Sodium Bisulfite, Ammonium Bisulfite, Sodium Metabisulfite and Potassium Metabisulfite¹
Bindu Nair and Amy R. Elmore

Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate¹

International Journal of Toxicology (ISSN 1091-5818), formerly the Journal of the American College of Toxicology, is published bimonthly by Informa Healthcare, 4th Floor, 27 Mortimer Street, London W1T 3JF, UK. Subscription is included with membership in the American College of Toxicology. Annual 2001 institutional subscription UK £270, US $445. Personal subscription rate UK £191, US $315 (available to home address only; must be paid for by personal check or credit card).

Addresses

Harihara M. Mehendale, Ph.D.
Editor-in-Chief
International Journal of Toxicology
Department of Toxicology
University of Louisiana at Monroe
Monroe LA 71209-0470 USA
Tel: 318-342-1691
Fax: 318-342-1686
e-mail: pymehendale@ulm.edu
Book Reviews: Robert W. Kapp, Jr., Ph.D.
President
BioTox
1810 A York Road
Suite 368
Lutherville, MD 21093-5165
Tel: 410-472-1722
Fax: 410-472-1723
e-mail: biotox@comcast.net
Subscriptions: Informa Healthcare
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UNITED STATES
Tel : +1 212 972 4899
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Informa Healthcare
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UNITED KINGDOM
Tel : +44 20 7017 5000