International Journal of Toxicology


Volume 16, Number 1
January-February 1997


CONTENTS
Editorial: A Thank You to Our Retiring Editor-in-Chief
Mildred S. Christian

Editorial
Harihara M. Mehendale

Dichlorvos and Mononuclear Cell Leukemia in Fischer 344 Rats: Lack of Effect of Chronic Administration on Progression of the Disease
Ann Manley, W. Ray Brown, and John Mennear

Efficacies of Atropine/2-PAM and Atropine/HI-6 in Treating Monkeys Intoxicated with Organophosphonate Nerve Agents
C. T. Olson, R. G. Menton, R. C. Kiser, M. C. Matthews, R. R. Stotts, J. R. Romano, I. Koplovitz, B. E. Hackley, and J. B. Johnson

Safety Pharmacology: Update on Scientific and Regulatory Issues
Introduction
Mildred S. Christian and Frances A. Mielach
Safety Pharmacology Approaches
Mark Hite
Problems Associated with the Absence of Activity in Standard Models of Safety Pharmacology Used to Assess Biologic Products
Martin D. Green
Safety Pharmacology Screening: Practical Problems in Drug Development
Lawrence I. Mortin, Christopher J. Horvath, and Michael S. Wyand

Book Review

Abstracts of the Seventeenth Annual Meeting of the American College of Toxicology

Announcement


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